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Efficient ballmill procedure in the 'green' asymmetric aldol reaction organocatalyzed by (S)prolinecontaining dipeptides in the presence of water ScienceDirect Abstract Introduction Section snippets References (27) Cited by (101) Tetrahedron Volume 67, Issue 36, 9 September 2011, Pages
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Aldol reaction is one of the most established reactions employed for the construction of new CC bond with application in chemical synthesis and biochemical domains. Conventionally, aldol reaction involved the use of basic catalyst in hydroalcoholic medium or use of strong bases in toxic and flammable organic solvents. Apart from long reaction times, such conditions result in mixtures of ...
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ChemInform Abstract: Efficient BallMill Procedure in the ′Green′ Asymmetric Aldol Reaction Organocatalyzed by (S)ProlineContaining Dipeptides in the Presence of Water. Article Sep 2011
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The slow aldol reaction of cyclohexanone with pnitro benzaldehyde and the fast aamination of isovaleraldehyde with dibenzyl azodicarboxylate have been selected as model reactions for this study. Prospects and limitations of the disclosed continuousflow organocatalytic approach are widely discussed.
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Efficient ballmill procedure in the 'green' asymmetric aldol reaction organocatalyzed by (S)prolinecontaining dipeptides in the presence of water. 2011, Tetrahedron ... prolinebased dipeptides 1ac has been evaluated in the asymmetric aldol reaction between representative ketones with various aromatic aldehydes under solventfree ...
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Recoverable (Sa)binamlprolinamide in combination with benzoic acid is used as catalysts in the direct aldol reaction between cycloalkyl, alkyl, and αfunctionalized ketones and aldehydes under solventfree reaction conditions. Three different methods are assayed: simple conventional magnetic stirring, magnetic stirring after previous dissolution in THF and evaporation, and ball mill ...
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As an environmentalfriendly and costeffective and green technology, ballmilling can be defined as a mechanical way of grinding material or composites into fine particles. 141, 142 It can be ...
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The organocatalytic asymmetric aldol reaction via an in situ generated enamine intermediate is one of the most powerful synthetic tools to achieve enantiomerically pure products.
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Introduction The aldol reaction is one of the most powerful and best known CC forming synthetic reactions, universally present in basic and advanced organic chemistry texts and amply reviewed in organic synthetic books and series. 14 The reaction has industrial relevance either in bulk production, or in the fine chemical and pharmaceutical industry. 5 The aldol reaction has a particular ...
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Efficient BallMill Procedure in the "Green" Asymmetric Aldol Reaction Organocatalyzed by (S)ProlineContaining Dipeptides in the Presence of Water Tetrahedron sept. de 2011 The organocatalytic activity of (S)prolinebased dipeptides 1ac has been evaluated in the asymmetric aldol reaction between representative ketones with various ...
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The desired aldol products were obtained in high yields (up to 94%) and good enantioselectivities (up to 97% ee). 17a In addition, Li and coworkers examined dipeptide ( 1c OH) in the asymmetric aldol reaction of different ketones and aldehydes in solid phase media (Al 2 O 3 ), using 1,4diazabicyclo[]octane as additive, observing ...
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However, the utilization of ball milling in asymmetric organic synthesis has not been adequately investigated. Thus, the aim of this review is to highlight the attractive features of the applications of mechanochemistry via ball milling in asymmetric organic syntheses in order to attract the attention of a wider section of the synthesis community.
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Efficient ballmill procedure in the 'green' asymmetric aldol reaction organocatalyzed by (S)prolinecontaining dipeptides in the presence of water. 2011 • ...,2R)Bis[(S)prolinamido]cyclohexane Modified with Ionic Groups: The First C2Symmetric Immobilized Organocatalyst for Asymmetric Aldol Reactions in Aqueous Media. 2011 • Sergei ...
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ChemInform Abstract: Efficient BallMill Procedure in the ′Green′ Asymmetric Aldol Reaction Organocatalyzed by (S)ProlineContaining Dipeptides in the Presence of Water. Citing article Sep 2011
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Highly efficient asymmetric aldol reaction in brine using a fluorous sulfonamide organocatalyst. Organic Biomolecular Chemistry 2012, 10, 2209. DOI: /c2ob06955e. ... Efficient ballmill procedure in the 'green' asymmetric aldol reaction organocatalyzed by (S)prolinecontaining dipeptides in the presence of water. ...
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The use of protonated lprolinethioamide instead of the free base derivative 1 as the organocatalyst for the direct aldol addition has a profound and appreciable effect on both the yield and the stereochemical course of the reaction. 4Nitrobenzaldehyde (2) reacts with acetone in the presence of the protonated catalyst, affording aldol ...
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Highly efficient asymmetric aldol reaction in brine using a fluorous sulfonamide organocatalyst. Organic Biomolecular Chemistry 2012, 10 ... Efficient ballmill procedure in the 'green' asymmetric aldol reaction organocatalyzed by (S)prolinecontaining dipeptides in the presence of water. Tetrahedron 2011, 67 ...
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Efficient ballmill procedure in the 'green' asymmetric aldol reaction organocatalyzed by ( S)prolinecontaining dipeptides in the presence of water. 2011 • ... these chiral ionic liquids could be applied as organocatalysts in asymmetric aldol reaction of 4 Available online 10 August 2012 nitrobenzaldehyde and acetone, and good yields ...
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The aldol reaction, which is used by nature for the building for substrate recognition and can present suitably placed of carbohydrate molecules through the use of aldolase hydrophobic and hydrophilic regions, as true enzymes enzymes,1 is a most useful synthetic procedure for the operating in aqueous, biological systems also construction ...
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An efficient, solventfree ballmilling protocol for the asymmetric aldol reaction between cyclohexanone and cyclopentanone with various aromatic aldehydes using a novel series of (S)prolinecontaining dipeptides and thiodipeptides 1af as organocatalysts is general, (S)prolinecontaining thiodipeptides proved to be better organocatalysts relative to their analogous amides.
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However, simple grinding is occasionally more efficient and economical than a similar method using milling technique, for example, quinazoline synthesis reported by Kuntikana et al. [80] took only a few min for completion under a solventfree condition while a similar reaction in a ballmill took several hours for completion [81].
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A highly efficient asymmetric organocatalytic aldol reaction in a ball mill . 2007;13 (17):471022. doi: / Authors Belén Rodríguez 1, Angelika Bruckmann, Carsten Bolm Affiliation 1 Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52056 Aachen, Germany. PMID: DOI: /
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A material supplier from Belgium would like to produce limestone powder for his custome...
India is rich in various mineral resources and it is an important mineral processing market
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